Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats

Abstract

Diabetes increases the risk of cardiovascular diseases. Berberine (BBR), an isoquinoline alkaloid used in Chinese medicine, exerts anti-diabetic effect by lowering blood glucose and regulating lipid metabolism. It has been reported that BBR decreases mortality in patients with chronic congestive heart failure. However, the molecular mechanisms of these… (More)
DOI: 10.1007/s10495-014-0977-0

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@article{Chen2014BerberineRI, title={Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats}, author={Keke Chen and Guohua Li and Fenghao Geng and Zhao Zhang and Jiani Li and Min Yang and Ling Dong and Feng Gao}, journal={Apoptosis}, year={2014}, volume={19}, pages={946-957} }