Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus

@inproceedings{Almani2017BerberinePA,
  title={Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus},
  author={Suhail Ahmed Almani and Iqbal Ahmed Memon and Tariq Zaffar Shaikh and Haji Khan Khoharo and Ikramuddin Ujjan},
  booktitle={Iranian journal of basic medical sciences},
  year={2017}
}
OBJECTIVES Causality of occurrence of metformin-associated lactic acidosis (MALA) is a clinical problem. Currently, there is no drug available to prevent MALA. The present study was conducted to evaluate the protective effect of Berberine (BBR) against MALA in induced diabetic rat model. MATERIALS AND METHODS A sample of 75 healthy male Wistar rats was randomly selected according to inclusion and exclusion criteria. 75 male Wistar rats were randomly divided into a control and 4 experimental… CONTINUE READING

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