Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells.

@article{Zhou2014BerberineMC,
  title={Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells.},
  author={Yan Zhou and Shijie Cao and Ying Wang and Peixiang Xu and Jiankun Yan and Wen Bin and Feng Qiu and Ning Kang},
  journal={Fitoterapia},
  year={2014},
  volume={92},
  pages={
          230-7
        }
}
Berberine (BBR) is an isoquinoline alkaloid isolated from several Chinese herbal medicines, such as Coptis chinensis, Berberis aristata, and Coptis japonica. It exhibits a lipid-lowering effect by up-regulating the hepatic low density lipoprotein receptor (LDLR) expression. However, the plasma concentration of BBR is very low after oral administration for the reason that BBR is poorly absorbed and rapidly metabolized. Therefore, it is hard to explain the pharmacological effects of BBR in vivo… CONTINUE READING

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