Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice

  title={Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice},
  author={Mei Xue and Liang Zhang and Ming-xing Yang and Wei Jun Zhang and Xiu-min Li and Zhi-min Ou and Zhi-peng Li and Su-huan Liu and Xue-jun Li and Shu-yu Yang},
  booktitle={International journal of nanomedicine},
Berberine (BBR) shows very low plasma levels after oral administration due to its poor absorption by the gastrointestinal tract. We have previously demonstrated that BBR showed increased gastrointestinal absorption and enhanced antidiabetic effects in db/db mice after being entrapped into solid lipid nanoparticles (SLNs). However, whether BBR-loaded SLNs (BBR-SLNs) also have beneficial effects on hepatosteatosis is not clear. We investigated the effects of BBR-SLNs on lipid metabolism in the… CONTINUE READING
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