Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis.

@article{Choi2008BerberineIH,
  title={Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis.},
  author={Myoung Suk Choi and Dong Yeon Yuk and Ju Hoon Oh and Hai Young Jung and Sang Bae Han and Dong Cheul Moon and Jin Tae Hong},
  journal={Anticancer research},
  year={2008},
  volume={28 6A},
  pages={3777-84}
}
Berberine, an alkaloid, has anti-tumor properties in some cancer cells, but action mechanisms are not clear yet. We here investigated the anticancer activity of berberine and possible mechanisms in human neuroblastoma SK-N-SH and SK-N-MC cells. The p53-expressing cells, SK-N-SH (IC50=37 microM) were more susceptible to berberine than the p53-deficient cells, SK-N-MC (IC50 > or =100 microM) without cytotoxic effect on the cortical neuronal cells. Berberine caused cell cycle arrest in G0/G1 phase… CONTINUE READING

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