• Corpus ID: 6906025

Berberine improves motor function recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis via AMPK activation in rats with spinal cord injury

  title={Berberine improves motor function recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis via AMPK activation in rats with spinal cord injury},
  author={Jiquan Wang and Ming-chao Zhang and Haotian Li and Gang Li and Zhi-qiang Jia and Ping Sun and Xingzhang Zhao and Gang Lv and Zhong-Kai Fan},
Evidences have supported the neuroprotective potential of berberine (BBR) in brain ischemia and injury. This study aimed to investigating whether BBR has neuroprotective effects on SCI and its mechanisms. Adult male Sprague-Dawley rats (220-250 g) were randomly divided into Sham, SCI, SCI + BBR (40 mg/kg/day), and SCI + BBR (40 mg/kg/day) + Compound C groups. The BBB score showed BBR improved functional recovery obviously 7 days later after SCI. Spinal cord tissue samples were harvested three… 

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