Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats.

@article{Mahmoud2017BerberineAM,
  title={Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats.},
  author={Ayman M Mahmoud and Walaa Gamal Hozayen and Shimaa M Ramadan},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2017},
  volume={94},
  pages={280-291}
}
Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits. It is one of the most effective natural supplements available; however, its ameliorative mechanism against methotrexate (MTX)-induced liver injury is not well defined. This study investigated the protective effect of BBR against MTX hepatotoxicity, focusing on its ability to attenuate oxidative stress and apoptosis and to activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase-1 (HO-1… CONTINUE READING
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