Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.

@article{Chao2019BerberineAN,
  title={Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.},
  author={Guanqun Chao and Fangxu Ye and Su-jiang Zhang},
  journal={Fundamental & clinical pharmacology},
  year={2019}
}
The study was to detect the role of GDNF, PGP9.5 (a neuronal marker) and GFAP (EGCs' marker) in the mechanism of NSAIDs related to intestinal injury, and to clarify the protective effect of berberine in the treatment of NSAID-induced small intestinal disease. 40 males SD rats were divided randomly into five groups (A-E): Group A: control group; Group B: model group received diclofenac sodium 7.5mg/(kg*d) for five days; Group C,D,E: berberine low, medium and high dose groups were treated by 7… CONTINUE READING