Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism

@article{Zhang2016BerberineAN,
  title={Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism},
  author={Xiuli Zhang and Dan Dan Liang and Xu Lian and Yan Jiang and Hui He and Wei Liang and Yongxi Zhao and Z Chi},
  journal={Apoptosis},
  year={2016},
  volume={21},
  pages={721-736}
}
Apoptosis of tubular epithelial cells is a major feature of diabetic kidney disease, and hyperglycemia triggers the generation of free radicals and oxidant stress in tubular cells. Berberine (BBR) is identified as a potential anti-diabetic herbal medicine due to its beneficial effects on insulin sensitivity, glucose metabolism and glycolysis. In this study, the underlying mechanisms involved in the protective effects of BBR on high glucose-induced apoptosis were explored using cultured renal… CONTINUE READING
Highly Cited
This paper has 34 citations. REVIEW CITATIONS