Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels

@article{Alzamora2011BerberineRC,
  title={Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels},
  author={Rodrigo Alzamora and Fiona O’Mahony and Wing-Hung Ko and Tiffany Wai-Nga Yip and Derek Carter and Mustapha Irnaten and Brian J Harvey},
  journal={Frontiers in Physiology},
  year={2011},
  volume={2}
}
Berberine is a plant alkaloid with multiple pharmacological actions, including antidiarrhoeal activity and has been shown to inhibit Cl− secretion in distal colon. The aims of this study were to determine the molecular signaling mechanisms of action of berberine on Cl− secretion and the ion transporter targets. Monolayers of T84 human colonic carcinoma cells grown in permeable supports were placed in Ussing chambers and short-circuit current measured in response to secretagogues and berberine… Expand
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