Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4

@article{Zhang2013BerberinePA,
  title={Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4},
  author={M. Zhang and C. Wang and J. Li and Zhao-jie Meng and Shengnan Wei and R. Bucala and Yu-lin Li and L. Chen},
  journal={Mediators of Inflammation},
  year={2013},
  volume={2013}
}
Endothelial dysfunction is a critical factor during the initiation of cardiovascular complications in diabetes. Berberine can ameliorate endothelial dysfunction induced by diabetes. However, the underlying mechanisms remain unclear. The aim of this study was to investigate the protective effect and mechanism of berberine on palmitate-induced endothelial dysfunction in human umbilical vein endothelial cells (HUVECs). The cell viability of HUVECs was determined by MTT assays. Nitric oxide (NOโ€ฆย Expand
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