Berberine Decreased Inducible Nitric Oxide Synthase mRNA Stability through Negative Regulation of Human Antigen R in Lipopolysaccharide-Induced Macrophages

@article{Shin2016BerberineDI,
  title={Berberine Decreased Inducible Nitric Oxide Synthase mRNA Stability through Negative Regulation of Human Antigen R in Lipopolysaccharide-Induced Macrophages},
  author={Ji-Sun Shin and Hye-Eun Choi and Seung-Hwan Seo and Jung-Hye Choi and N. Baek and K. Lee},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2016},
  volume={358},
  pages={13 - 3}
}
Berberine, a major isoquinoline alkaloid found in medicinal herbs, has been reported to possess anti-inflammatory effects; however, the underlying mechanisms responsible for its actions are poorly understood. In the present study, we investigated the inhibitory effects of berberine and the molecular mechanisms involved in lipopolysaccharide (LPS)-treated RAW 264.7 and THP-1 macrophages and its effects in LPS-induced septic shock in mice. In both macrophage cell types, berberine inhibited the… Expand
Berberine ameliorates lipopolysaccharide‐induced acute lung injury via the PERK‐mediated Nrf2/HO‐1 signaling axis
Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)

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