• Corpus ID: 41795485

Berberine-Containing Herbs and Pregnancy

  title={Berberine-Containing Herbs and Pregnancy},
  • Published 2007
  • Biology
Berberine-containing herbs such as golden seal (Hydrastis canadensis) and barberry (Berberis vulgaris) are traditionally said to be contraindicated in pregnancy. The British Herbal Pharmacopoeia 1983 is one such source of this information. In most earlier texts or articles it is not always clear as to why this contraindication might exist. Certainly in the case of golden seal the concern was that its reputed oxytocic effect might induce premature labor. But since this activity was largely… 
2 Citations

Toxicology effects of Berberis vulgaris (barberry) and its active constituent, berberine: a review

Data from the present study indicate that B. vulgaris and berberine toxicity is depending on the route and duration of administration, and they could induce GI upset and ulceration, immunot toxicity, phototoxicity, neurotoxicity, cardiotoxicity and jaundice in a dose dependent manner.

The protective effect of berberine against lipopolysaccharide-induced abortion by modulation of inflammatory/immune responses

The results suggest that berberine as an anti-inflammatory agent has protective effects on LPS-induced abortion by modulation of inflammatory/immune responses.



Displacement of bilirubin from albumin by berberine.

  • E. Chan
  • Medicine, Biology
    Biology of the neonate
  • 1993
Berberine was found in vitro, as to its displacing effect on a molar basis, to be about tenfold superior to phenylbutazone, a known potent displacer of bilirubin, and about hundredfold to papaverine, a berberine-type alkaloid.

A reproductive screening test of goldenseal.

The data suggest that goldenseal, at the prescribed human dose, is unlikely to be absorbed to an extent to be unsafe to use in pregnancy despite the apparent cytotoxic effects in vitro, and indicate that pharmacokinetic studies are required to confirm this conclusion.

Herbal Medicines Used During the First Trimester and Major Congenital Malformations

Evidence is found for a possible link between the use of specific herbal medicines during the first trimester of pregnancy and increased risks of specific groups of congenital malformations.

Induction of labor.

Herbal Medicine Association’s Scientific Committee

  • British Herbal Pharmacopoeia. BHMA, Bournemouth,
  • 1983

Do herbal remedies have an adverse effect on pregnancy outcome in the rat ?

  • Final Study Report Developmental Toxicity Evaluation for Berberine Chloride Dihydrate ( Cas No . 5956605 ) Administered by Gavage to SpragueDawley ( CD  ) Rats on Gestational Days 6 through 19 Final Study Report Developmental Toxicity Evaluation for Goldenseal ( Hydrastis canadensis ) Root Powder A

Developmental toxicity evaluation of berberine chloride dehydrate ( BCD ) in SpragueDawley ( CD ) rats [ abstract ]

  • Biol Neonate
  • 1993

Do herbal remedies have an adverse effect on pregnancy outcome in the rat? Teratology

  • 2001