Berbanes: search for novel alpha-2 adrenoceptor antagonists.

@article{Hrsing1988BerbanesSF,
  title={Berbanes: search for novel alpha-2 adrenoceptor antagonists.},
  author={L{\'a}szl{\'o} G{\'a}bor H{\'a}rsing and G Lonart and Sylvester E. Vizi},
  journal={Polish journal of pharmacology and pharmacy},
  year={1988},
  volume={40 6},
  pages={697-708}
}
We have previously described the alpha-2 adrenoceptor antagonist properties of berbanes and its stereoisomers. Of the compounds studied CH-38083 (2,3-methylenedioxy-11-betahydroxyalloberbane) has been selected for further analysis based upon its high affinity and selectivity for central and peripheral alpha-2 adrenoceptors. Structure activity relationship… CONTINUE READING