Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis

@article{Zhao2016BerbamineIT,
  title={Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis},
  author={Yan-yan Zhao and Jiajia Lv and Jinghong Chen and Xiao bing Jin and Mei Wei Wang and Zhipeng Su and Luo Yi Wang and Hui Zhang},
  journal={Prostate Cancer and Prostatic Diseases},
  year={2016},
  volume={19},
  pages={358-366}
}
Background:Berbamine (BBM) has been reported with antitumor activities. BBM inhibited the growth of prostate cancer (PCa) cells and caused vacuolization of mitochondria in preliminary study. We hypothesized BBM could enhance apoptosis of PCa cells through mitochondrial pathway.Methods:Growth of PC-3 and LNCaP cells treated by BBM was determined by cell viability assay. The morphology of mitochondria was observed by electron microscopy. Apoptosis was quantified by flow cytometry. Expressions of… CONTINUE READING
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