Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates lipopolysaccharide-induced cellular injury in lung alveolar epithelial cells.

@article{Vicil2015BeraprostSA,
  title={Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates lipopolysaccharide-induced cellular injury in lung alveolar epithelial cells.},
  author={Sinan Vicil and Suat Erdogan},
  journal={Turkish journal of medical sciences},
  year={2015},
  volume={45 2},
  pages={
          284-90
        }
}
BACKGROUND/AIM Human alveolar epithelial cells play a critical role in the pathogenesis of lung diseases. The objective of this study is to determine the contribution of beraprost sodium, a prostaglandin I2 (PGI2) analogue, to inflammatory and oxidative events in response to lipopolysaccharide (LPS) in airway epithelial cells. MATERIALS AND METHODS Human pulmonary alveolar epithelial cells (A549) were pretreated with 10 µM beraprost sodium 30 min before stimulation with 1 µg/mL LPS for 24 h… CONTINUE READING

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