Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure-activity relationship study.

@article{Turpaev2011BenzylidenemalononitrileCA,
  title={Benzylidenemalononitrile compounds as activators of cell resistance to oxidative stress and modulators of multiple signaling pathways. A structure-activity relationship study.},
  author={Kyril T. Turpaev and Mikhail Ermolenko and Thierry Cresteil and Jean Claude Drapier},
  journal={Biochemical pharmacology},
  year={2011},
  volume={82 5},
  pages={535-47}
}
Benzylidenemalononitrile (BMN) tyrphostins are well known as potent tyrosine kinase inhibitors. Moreover, in recent years it has been recognized that members of the tyrphostin family possess additional biological activities independent of their ability to inhibit protein tyrosine kinases. In this study, we examined the relationship between the structure of 49 BMNs and related compounds, and their capacity to induce heme oxygenase 1 (HO-1) gene expression in U937 human monocytic cells, to… CONTINUE READING