Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells.

@article{Xiao2008BenzylIT,
  title={Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells.},
  author={Dong Xiao and Anna A. Powolny and Shivendra V Singh},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 44},
  pages={30151-63}
}
Benzyl isothiocyanate (BITC), a dietary cancer chemopreventive agent, causes apoptosis in MDA-MB-231 and MCF-7 human breast cancer cells, but the mechanism of cell death is not fully understood. We now demonstrate that the BITC-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species (ROS) due to inhibition of complex III of the mitochondrial respiratory chain. The BITC-induced ROS production and apoptosis were significantly inhibited by overexpression of catalase… CONTINUE READING

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The BITC treatment caused activation of c - Jun N - terminal kinase ( JNK ) and p38 mitogen - activated protein kinase ( MAPK ) , which function upstream of Bax activation in apoptotic response to various stimuli .
The BITC treatment caused activation of c - Jun N - terminal kinase ( JNK ) and p38 mitogen - activated protein kinase ( MAPK ) , which function upstream of Bax activation in apoptotic response to various stimuli .
The BITC treatment caused activation of c - Jun N - terminal kinase ( JNK ) and p38 mitogen - activated protein kinase ( MAPK ) , which function upstream of Bax activation in apoptotic response to various stimuli .
The BITC treatment caused activation of c - Jun N - terminal kinase ( JNK ) and p38 mitogen - activated protein kinase ( MAPK ) , which function upstream of Bax activation in apoptotic response to various stimuli .
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