Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3.

@article{Kim2011BenzylII,
  title={Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3.},
  author={Su-Hyeong Kim and Arumugam Nagalingam and Neeraj Saxena and Shivendra V Singh and Dipali Sharma},
  journal={Carcinogenesis},
  year={2011},
  volume={32 3},
  pages={359-67}
}
Molecular effects of obesity, a well-established risk factor for breast cancer progression, are mediated by adipocytokine leptin. Given the important role of leptin in breast cancer growth and metastasis, novel strategies to antagonize biological effects of this adipocytokine are much desired. We showed previously that benzyl isothiocyanate (BITC), a constituent of edible cruciferous vegetables (e.g. garden cress), confers significant protection against mammary carcinogenesis in a transgenic… CONTINUE READING