Benzyl isothiocyanate disturbs lipid metabolism in rats in a way independent of its thyroid impact following in vivo long-term treatment and in vitro adipocytes studies

  title={Benzyl isothiocyanate disturbs lipid metabolism in rats in a way independent of its thyroid impact following in vivo long-term treatment and in vitro adipocytes studies},
  author={Monika Okulicz and Iwona Hertig},
  journal={Journal of Physiology and Biochemistry},
During recent decades, benzyl isothiocyanate (BITC) was examined mainly in terms of its cancer chemopreventive action. Although some research has been conducted on goitrogenic activity of many glucosinolate derivatives, little attention has been paid to the BITC impact on the thyroid gland and lipid metabolism strictly associated with it. Therefore, this research project aimed at expanding our knowledge about how non-physiological doses of BITC (widely used in chemotherapy) influence some… Expand
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Benzyl Isothiocyanate Produced by Garden Cress (Lepidium sativum) Prevents Accumulation of Hepatic Lipids.
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Natural compounds that modify the activity of the Nrf2 pathway should be evaluated carefully, not only for their potential to be used as therapeutic agents for thyroid disorders, but also for their thyroidal safety when used for the prevention and treatment of non-thyroidal diseases. Expand
Benzyl isothiocyanate suppresses high‐fat diet‐stimulated mammary tumor progression via the alteration of tumor microenvironments in obesity‐resistant BALB/c mice
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Genotoxic effects of benzyl isothiocyanate, a natural chemopreventive agent.
Investigation of the genotoxic effects ofBenzyl isothiocyanate showed that this compound causes formation of thiobarbituric acid-reactive substances in HepG2 cells and that its DNA damaging properties are diminished by alpha-tocopherol, vitamin C, sodium benzoate and beta-carotene, indicating the possible involvement of free radicals in thegenotoxicity of BITC. Expand
Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action.
  • Y. Zhang
  • Chemistry, Medicine
  • Mutation research
  • 2004
ITCs possess multiple anticarcinogenic mechanisms, including inhibition of carcinogen-activating enzymes, induction of carcinogens-detoxifying enzymes, increase of apoptosis, arrest of cell cycle progression, as well as several other mechanisms that are not yet fully described. Expand
Involvement of Toxicity as an Early Event in Urinary Bladder Carcinogenesis Induced by Phenethyl Isothiocyanate, Benzyl Isothiocyanate, and Analogues in F344 Rats
Investigation of early changes in rat urinary bladder epithelium induced by PEITC and BITC suggests that continuous urinary epithelial cell proliferation due to cytotoxicity may play an important role in the early stage ofRat urinary bladder carcinogenesis due to oral administration of ITCs. Expand
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Subacute oral toxicity study of benzyl isothiocyanate in rats.
The subacute toxicity of benzyl isothiocyanate (BITC) was investigated in male rats given oral doses of 0, 50, 100 and 200 mg/kg body weight/day for 4 weeks. Body weight gain and food consumptionExpand