Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro.

  title={Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro.},
  author={Satyan S. Kalkunte and Narasimha Swamy and Don S Dizon and Laurent Brard},
  journal={Journal of experimental therapeutics & oncology},
  volume={5 4},
Advanced ovarian cancer (OC) is not curable by surgery alone and chemotherapy is essential for its treatment. Isothiocyanates have been shown to inhibit carcinogen-induced tumorigenesis in animal models, yet no efforts have been made to determine their therapeutic potential in OC. In the present study, we investigated the mechanism of the anti-proliferative and apoptotic activity of benzyl isothiocyanate (BITC) in OC. BITC inhibited the proliferation of OC cells and induced apoptosis in OC… CONTINUE READING
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