Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris

@article{Sagransky2009BenzoylPA,
  title={Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris},
  author={Matthew J. Sagransky and Brad A. Yentzer and Steven R. Feldman},
  journal={Expert Opinion on Pharmacotherapy},
  year={2009},
  volume={10},
  pages={2555 - 2562}
}
Background: Owing to the use of topical and systemic antibiotics for acne vulgaris, the incidence of antibiotic-resistant Propionibacterium acnes is increasing worldwide. Topical benzoyl peroxide (BPO) is an alternative to antibiotics in the treatment of acne vulgaris. Objective: This review describes and evaluates recent clinical literature regarding the efficacy and tolerability of BPO. Methods: A PubMed literature search was conducted using the keywords benzoyl peroxide, acne, and… 
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88 Citations
Highly Influential Citations
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Background Citations
19
Methods Citations
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Results Citations
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88 Citations

Topical acne treatments in Europe and the issue of antimicrobial resistance

An update on the current topical acne treatments available in Europe, their mechanism of action, their potential to induce antimicrobial resistance and their clinical efficacy and safety are provided.

Adverse events related to topical drug treatments for acne vulgaris

The most commonly reported AEs were associated with local skin irritation, usually mild to moderate in intensity, intermittent, and rarely led to the cessation of therapy, which seems to be highest for BPO and topical retinoids.

Intense pulsed light versus benzoyl peroxide 5 % gel in treatment of acne vulgaris

Treatment with both benzoyl peroxide and IPL resulted in considerable improvement of the acne after 5 weeks of treatment, and comparing the effects of both therapies, BP produced better results than IPL.

Clinical evaluation of efficacy and safety of a polyherbal formulation in acne vulgaris

The safety and efficacy of a Polyherbal Formulation in comparison to benzoyl peroxide in the management of Acne Vulgaris was assessed by Cook’s acne grading scale.

Adapalene 0.1% and benzoyl peroxide 2.5% combination gel for the treatment of acne vulgaris

Results from clinical trials provide robust evidence that this fixed-dose combination gel is significantly more efficacious than its corresponding monotherapies and has a mild tolerability profile similar to that of adapalene alone.

Topical benzoyl peroxide for acne.

Based on low-certainty evidence, there may be little to no difference between BPO and adapalene, and for 'participant-reported acne improvement', BPO may be more effective than placebo or no treatment.

Overview of the Treatment of Acne Vulgaris with Topical Retinoids

Evidence is provided to buttress the contention that clinical outcomes will be improved if topical retinoids are utilized in patients with acne vulgaris.

Efficacy of benzoyl peroxide and clindamycin combination therapy with benzoyl peroxide alone in the treatment of acne vulgaris

It can be concluded that the drug, benzoyl peroxide when used individually, was found to be effective in the treatment of acne, but the combination of the two clindamycin and benzoyL peroxide was finding to be superior in efficacy.

Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris

The addition of SA to CDP and BPO treatment demonstrated significantly better and faster results in terms of reductions in acne lesion counts and well tolerated except for higher frequency of mild to moderate transient dryness.

Treating acne with antibiotic-resistant bacterial colonization

This review discusses the pathophysiology of antibiotic-resistant acne development and focuses on strategies to minimize the development of resistance and, most importantly, confront the developmentof antibiotic- resistant acne.
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References

SHOWING 1-10 OF 74 REFERENCES

Benzoyl Peroxide-Based Combination Therapies for Acne Vulgaris

Combination products containing benzoyl peroxide and the topical antibiotics have been shown to both prevent the development of antibiotic resistance in acne patients; and confer significant clinical improvement to patients who have already developed antibiotic resistance.

Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid

  • W. WorretJ. Fluhr
  • Medicine
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
  • 2006
Benzoyl peroxide is safe for use in pregnant and lactating females because it is degraded to benzoic acid, and is a cost‐effective treatment for acne grade I–II.

Benzoyl Peroxide, Adapalene, and Their Combination in the Treatment of Acne Vulgaris

The study revealed that all three therapy protocols were effective in treating noninflammatory and inflammatory lesions in acne vulgaris and that there was no significant difference between the groups in efficacy or side effects (p>0.05).

Topical antibiotics for the treatment of acne vulgaris: A critical evaluation of the literature on their clinical benefit and comparative efficacy

To determine whether topical antibiotics could be ranked in order of therapeutic efficacy and to determine the relative efficacy of topical antibiotics compared with oral tetracycline and topical benzoyl peroxide, pooling data from different studies was undertaken.

Current Options for the Topical Treatment of Acne Vulgaris

  • J. Weiss
  • Biology
    Pediatric dermatology
  • 1997
A group of retinoids that include adapalene, tazarotene, and reformulations of tretinoin represent new and forthcoming agents for topical treatment of acne vulgaris and some studies indicate that several of these agents are associated with less skin irritation than previous formulations while they retain potent comedoiytic activity.

Synergistic Activity of Benzoyl Peroxide and Erythromycin

It is proposed that the tertiary amines contained on certain antibiotics are responsible for catalysis of BP radical formation, and this data reveal the possibility of a biological synergism in mixtures of BP and antibiotics.

Guidelines for the Management of Acne Vulgaris in Adolescents

Over recent years dermatologists have increasingly used this drug to treat patients with moderate acne which has not responded to other systemic therapies, particularly when associated with scarring or significant psychological disability, but this use is outside the current license of the drug.

Antibiotic-resistant Propionibacterium acnes suppressed by a benzoyl peroxide cleanser 6%.

Benzoyl peroxide cleanser 6% effectively reduced resistant P acnes populations and offers a useful therapy for controlling antibiotic resistance in patients receiving antibiotics.

Comparing 2.5%, 5%, and 10% Benzoyl Peroxide on Inflammatory Acne Vulgaris

The 2.5% benzoyl peroxide formulation was more effective than its vehicle and equivalent to the 5% and 10% concentrations in reducing the number of inflammatory lesions (papules and pustules).

The short‐term treatment of acne vulgaris with benzoyl peroxide: effects on the surface and follicular cutaneous microflora

The results indicate that significant reductions in surface and follicular microorganisms may be obtained after 48 h treatment with BP, and the non‐specific antibacterial action of BP may be utilized in short intervening courses to reduce the carriage of antibiotic‐resistant micro‐organisms and thus improve the long‐term efficacy of antibiotic acne treatments.
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