Benzotriazole-Mediated Synthesis and Antibacterial Activity of Novel N-Acylcephalexins


Cephalexin (1) was acylated using N-acylbenzotriazoles (3a-k') derived from various carboxylic acids including aromatic, heterocyclic and N-Pg-α-amino acid to afford N-acylcephalexins in excellent yields (82%-96%). Antibacterial screening of the novel cephalosporins revealed that all targets (4a-j) retained the antibacterial activity of cephalexin against… (More)
DOI: 10.3390/scipharm84030484


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