Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells.

@article{Sadikovi2006BenzopyreneED,
  title={Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells.},
  author={Bekim Sadikovi{\'c} and David I. Rodenhiser},
  journal={Toxicology and applied pharmacology},
  year={2006},
  volume={216 3},
  pages={458-68}
}
Exposures to environmental carcinogens and unhealthy lifestyle choices increase the incidence of breast cancer. One such compound, benzo(a)pyrene (BaP), leads to covalent DNA modifications and the deregulation of gene expression. To date, these mechanisms of BaP-induced carcinogenesis are poorly understood, particularly in the case of breast cancer. We tested the effects of BaP exposure on cellular growth dynamics and DNA methylation in four breast cancer cell lines since disruptions in DNA… CONTINUE READING

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