Benzofuran-morpholinomethyl-pyrazoline hybrids as a new class of vasorelaxant agents: synthesis and quantitative structure-activity relationship study.

@article{Hassan2014Benzofuranmorpholinomethylpyrazolin,
  title={Benzofuran-morpholinomethyl-pyrazoline hybrids as a new class of vasorelaxant agents: synthesis and quantitative structure-activity relationship study.},
  author={Ghaneya Sayed Hassan and Doaa Ezzat Rahman and Dalia Osama Abdel Saleh and Gehad Abdel Raheem Abdel Jaleel},
  journal={Chemical & pharmaceutical bulletin},
  year={2014},
  volume={62 12},
  pages={1238-51}
}
The benzofuran-morpholinomethyl-pyrazoline hybrids 4a-e, 5a-e and 6a-j were synthesized via reaction of α,β-unsaturated carbonyl compounds 3a-e with hydrazine hydrate, semicarbazide or thiosemicarbazide. Applying the Mannich reaction to 5-(5-aryl-4,5-dihydro-1H-pyrazol-3-yl)-4-methoxybenzofuran-6-ols 7a-e with morpholine hydrochloride and paraformaldehyde… CONTINUE READING