Benzodiazepines in epilepsy: pharmacology and pharmacokinetics

@article{Riss2008BenzodiazepinesIE,
  title={Benzodiazepines in epilepsy: pharmacology and pharmacokinetics},
  author={Jennifer R. Riss and James C. Cloyd and John R. Gates and Stephen D. Collins},
  journal={Acta Neurologica Scandinavica},
  year={2008},
  volume={118}
}
Benzodiazepines (BZDs) remain important agents in the management of epilepsy. They are drugs of first choice for status epilepticus and seizures associated with post‐anoxic insult and are also frequently used in the treatment of febrile, acute repetitive and alcohol withdrawal seizures. Clinical advantages of these drugs include rapid onset of action, high efficacy rates and minimal toxicity. Benzodiazepines are used in a variety of clinical situations because they have a broad spectrum of… 
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TLDR
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Oral levetiracetam provided seizure control relative to placebo as adjunctive therapy in patients with idiopathic generalized epilepsy with myoclonic seizures or GTC seizures and showed improvements in measures of health-related quality of life relative to those receiving placebo.
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