Benzodiazepines for PTSD: A Systematic Review and Meta-Analysis

@article{Rossetter2015BenzodiazepinesFP,
  title={Benzodiazepines for PTSD: A Systematic Review and Meta-Analysis},
  author={Sarah R Rossetter and Bethany J. DeRHODES and Randon S. Welton},
  journal={Journal of Psychiatric Practice},
  year={2015},
  volume={21},
  pages={281–303}
}
Objective: Although benzodiazepines (BZDs) are commonly used in the treatment of posttraumatic stress disorder (PTSD), no systematic review or meta-analysis has specifically examined this treatment. The goal of this study was to analyze and summarize evidence concerning the efficacy of BZDs in treating PTSD. Methods: The review protocol was undertaken according to the principles recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and is… 
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References

SHOWING 1-10 OF 56 REFERENCES
Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: A systematic review
Do benzodiazepines reduce the effectiveness of exposure therapy for posttraumatic stress disorder?
TLDR
Prolonged exposure is a sufficiently robust treatment that patients who are taking benzodiazepines can benefit from it, andBenzodiazepine recipients' poorer maintenance of gains in present-centered psychotherapy is identified.
Posttraumatic stress disorder in general intensive care unit survivors: a systematic review.
Pharmacotherapy for posttraumatic stress disorder: review with clinical applications.
TLDR
The pharmacotherapy recommendations from the 2010 revised Department of Veterans Affairs/Department of Defense Clinical Practice Guideline for PTSD are reviewed and practical PTSD treatment recommendations for clinicians are provided.
Treatment of recent trauma survivors with benzodiazepines: a prospective study.
TLDR
The early administration of benzodiazepines to trauma survivors with high levels of initial distress did not have a salient beneficial effect on the course of their illness, while reducing physiologic expression of arousal.
Clonazepam for Treatment of Sleep Disturbances Associated with Combat-Related Posttraumatic Stress Disorder
TLDR
Clonazepam therapy was largely ineffective in improving sleep disturbances, particularly nightmares, associated with combat-related PTSD, and further studies are needed to further define the role of this widespread clinical practice.
Pharmacologic treatment of posttraumatic stress disorder among privately insured Americans.
TLDR
Although use targeted specifically to PTSD and to comorbid disorders was common, substantial use appeared to be unrelated to diagnosis and may be targeted at specific symptoms rather than diagnosed illnesses.
Effects of the benzodiazepine antagonist flumazenil in PTSD
Patient and facility characteristics associated with benzodiazepine prescribing for veterans with PTSD.
TLDR
Interventions could be designed to target individual high-volume prescribers or influence prescribing culture at the facility level to ensure consistent access to guideline-concordant PTSD treatment across the VHA.
Substance use disorders in patients with posttraumatic stress disorder: a review of the literature.
TLDR
Vigorous control of withdrawal and PTSD-related arousal symptoms should be sought during detoxification of patients with comorbid PTSD and substance use disorders.
...
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