Benzodiazepines and heightened aggressive behavior in rats: reduction by GABA(A)/alpha(1) receptor antagonists.

@article{Gourley2005BenzodiazepinesAH,
  title={Benzodiazepines and heightened aggressive behavior in rats: reduction by GABA(A)/alpha(1) receptor antagonists.},
  author={Shannon L Gourley and Joseph F. Debold and Wenyuan Yin and James M Cook and Klaus A Miczek},
  journal={Psychopharmacology},
  year={2005},
  volume={178 2-3},
  pages={
          232-40
        }
}
RATIONALE Positive modulators of the benzodiazepine/GABA(A) receptor complex can heighten aggressive behavior; the GABA(A)/alpha(1) subunit may play a critical role in benzodiazepine-modulated aggressive behavior. OBJECTIVE The carboline derivatives, beta-CCt and 3-PBC, antagonists with preferential action at the GABA(A) receptors with alpha(1) subunits, may antagonize benzodiazepine-heightened aggression, thus implicating the alpha(1) subunit in heightened aggression. METHODS The GABA(A… CONTINUE READING

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