Benzodiazepines and anterior pituitary function

  title={Benzodiazepines and anterior pituitary function},
  author={E. Arvat and R. Giordano and S. Grottoli and E. Ghigo},
  journal={Journal of Endocrinological Investigation},
  • E. Arvat, R. Giordano, +1 author E. Ghigo
  • Published 2002
  • Biology, Medicine
  • Journal of Endocrinological Investigation
  • Benzodiazepines (BDZ) are one of the most prescribed classes of drugs because of their marked anxiolytic, anticonvulsant, muscle relaxant and hypnotic effects. The pharmacological actions of BDZ depend on the activation of 2 specific receptors. The central BDZ receptor, present in several areas of the central nervous system (CNS), is a component of the GABA-A receptor, the activation of which increases GABAergic neurotransmission and is followed by remarkable neuroendocrine effects. The… CONTINUE READING
    46 Citations
    GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations
    • 45
    • PDF
    Neuroregulation of the Hypothalamus-Pituitary-Adrenal (HPA) Axis in Humans: Effects of GABA-, Mineralocorticoid-, and GH-Secretagogue-Receptor Modulation
    • 72
    • PDF
    Hypothalamic-pituitary-adrenocortical axis: neuropsychiatric aspects.
    • L. Jacobson
    • Psychology, Medicine
    • Comprehensive Physiology
    • 2014
    • 99
    • PDF
    Alprazolam (a benzodiazepine activating GABA receptor) reduces the neuroendocrine responses to insulin‐induced hypoglycaemia in humans
    • 33
    Effects of dehydroepiandrosterone and alprazolam on hypothalamic-pituitary responses to exercise.
    • 21
    • PDF


    Selective antagonists of benzodiazepines
    • 1,187
    Effects of chronic antidepressant and benzodiazepine treatment on corticotropin-releasing-factor receptors in rat brain and pituitary.
    • 50
    Interaction of benzodiazepines with neuroleptics at central dopamine neurons
    • 26
    GABA receptors: are cellular differences reflected in function?
    • 178