Benzodiazepine treatment causes uncoupling of recombinant GABAA receptors expressed in stably transfected cells.

@article{Klein1994BenzodiazepineTC,
  title={Benzodiazepine treatment causes uncoupling of recombinant GABAA receptors expressed in stably transfected cells.},
  author={Ronald L. Klein and Paul John Whiting and R. Adron Harris},
  journal={Journal of neurochemistry},
  year={1994},
  volume={63 6},
  pages={2349-52}
}
GABAA and benzodiazepine receptors are allosterically coupled, and occupation of either receptor site increases the affinity of the other. Chronic exposure of primary neuronal cultures to benzodiazepine agonists reduces these allosteric interactions. Neurons express multiple GABAA receptor subunits, and it has been suggested that uncoupling is due to… CONTINUE READING