Benzodiazepine receptor protein identified and visualized in brain tissue by a photoaffinity label.

@article{Mhler1980BenzodiazepineRP,
  title={Benzodiazepine receptor protein identified and visualized in brain tissue by a photoaffinity label.},
  author={Hanns M{\"o}hler and M K Battersby and J. Grayson Richards},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 3},
  pages={1666-70}
}
Flunitrazepam, a potent benzodiazepine, reversibly binds to the benzodiazepine receptor with high affinity. When irradiated with UV light, flunitrazepam was irreversibly linked to brain tissue. Incorporation of [3H]flunitrazepam was inhibited by other benzodiazepines with a potency corresponding to their affinity for the benzodiazepine receptor. Photolabeling with flunitrazepam reduced the number of benzodiazepine receptors determined by reversible binding of benzodiazepines, whereas the… CONTINUE READING

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