Benzodiazepine receptor photoaffinity labeling: correlation of function with binding.

@article{Gibbs1985BenzodiazepineRP,
  title={Benzodiazepine receptor photoaffinity labeling: correlation of function with binding.},
  author={Terrell T. Gibbs and Cecilia K. Y. Chan and Cynthia Czajkowski and David H. Farb},
  journal={European journal of pharmacology},
  year={1985},
  volume={110 2},
  pages={171-80}
}
Exhaustive photoaffinity coupling of flunitrazepam to living spinal cord neurons reduced the capacity of benzodiazepines to potentiate the electrophysiologically measured GABA response. In qualitative agreement with reversible binding data the dose-response curve for enhancement of the GABA response by benzodiazepines was shifted to the right, indicating that the remaining reversible benzodiazepine binding sites have lower affinity for benzodiazepines. Photoaffinity labeling did not reduce… CONTINUE READING