Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy.

@article{Yurdaydin1993BenzodiazepineRL,
  title={Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy.},
  author={Cihan Yurdaydin and Zhinan Gu and Gabriel Nowak and Claudia Fromm and A. G. J. Holt and Anthony S. Basile},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={265 2},
  pages={565-71}
}
Elevated levels of benzodiazepine receptor agonists are found in both animal models of hepatic encephalopathy and in humans with this syndrome. The present study investigated the relationship between agonist levels and the severity of the encephalopathy, as well as the potential reversibility of the syndrome by benzodiazepine receptor antagonists. The concentrations of benzodiazepine receptor ligands in rat brains were measured at several intervals during the induction of liver failure with… CONTINUE READING