Benzodiazepine receptor ligand actions on GABA responses. β-carbolines, purines

@article{Skerritt1984BenzodiazepineRL,
  title={Benzodiazepine receptor ligand actions on GABA responses. $\beta$-carbolines, purines},
  author={J. Skerritt and R. Macdonald},
  journal={European Journal of Pharmacology},
  year={1984},
  volume={101},
  pages={135-141}
}
Abstract The effects of several β-carboline and purine ligands for benzodiazepine receptors were studied upon GABA (4-aminobutyric acid) responses and upon diazepan enhancement of GABA responses, using mouse spinal cord neurons in dissociated cell culture. While the potent convulsant β-carboline DMCM (methyl-6,7-dimethyoxy-4-ethyl-carboline-3-carboxylate), reduced GABA responses, methyl-carboline-3-carboxylate (βCCMe) and the corresponding ethyl ester (βCCEt) did not alter GABA responses. The… Expand
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