Benzodiazepine metabolism: an analytical perspective.

  title={Benzodiazepine metabolism: an analytical perspective.},
  author={Roberto Mandrioli and Laura Mercolini and Maria Augusta Raggi},
  journal={Current drug metabolism},
  volume={9 8},
Benzodiazepines are currently among the most frequently prescribed drugs all over the world. They act as anxiolytics, sedatives, hypnotics, amnesics, antiepileptics and muscle relaxants. Despite their common chemical scaffold, these drugs differ in their pharmacokinetic and metabolic properties. In particular, they are biotransformed by different cytochrome P450 isoforms and also by different UDP-glucuronosyltransferase subtypes. The most important studies on the metabolic characteristics of… CONTINUE READING