Benzodiazepine-induced sedation and cortisol suppression

@article{Christensen2005BenzodiazepineinducedSA,
  title={Benzodiazepine-induced sedation and cortisol suppression},
  author={P. Christensen and Anette Lolk and Lars Freng Gram and Per Kragh‐S{\o}rensen},
  journal={Psychopharmacology},
  year={2005},
  volume={106},
  pages={511-516}
}
The sedative and cortisol suppressing properties of oxazepam (45 and 60 mg) and nitrazepam (10 and 15 mg) were examined in eight healthy male subjects. The most clear differences between oxazepam and nitrazepam were those seen with respect to the time course and until maximal effect (Tmax) of the different measurements. Nitrazepam showed maximal sedation after 1 h, maximal benzodiazepine level (RRA), and reaction time prolongation after 2 h, and maximal cortisol suppression after 3 h. Oxazepam… 

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