Benzodiazepine and beta-carboline interactions with GABAA receptor-gated chloride channels in mammalian cultured spinal cord neurons.

@article{Mehta1989BenzodiazepineAB,
  title={Benzodiazepine and beta-carboline interactions with GABAA receptor-gated chloride channels in mammalian cultured spinal cord neurons.},
  author={Ashok Kumar Mehta and Maharaj K. Ticku},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1989},
  volume={249 2},
  pages={
          418-23
        }
}
The interaction of benzodiazepine (BZ) and beta carbolines with GABAA receptor-gated chloride channels using 36Cl influx biochemical functional assay in mammalian spinal cord cultured neurons was investigated. BZ-receptor agonists such as flunitrazepam, diazepam, clonazepam and flurazepam enhanced the effect of submaximal concentrations of GABA (10 microM)-stimulated 36Cl influx. The rank order of potencies was flunitrazepam greater than clonazepam greater than diazepam greater than flurazepam… CONTINUE READING

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