Benzodiazepine Withdrawal Reaction in Two Children following Discontinuation of Sedation with Midazolam

@article{Engelen1993BenzodiazepineWR,
  title={Benzodiazepine Withdrawal Reaction in Two Children following Discontinuation of Sedation with Midazolam},
  author={B. V. van Engelen and J. Gimbr{\`e}re and L. H. Booy},
  journal={Annals of Pharmacotherapy},
  year={1993},
  volume={27},
  pages={579 - 581}
}
OBJECTIVE: To report the occurrence of recurrent benzodiazepine withdrawal reactions in two very young children following discontinuation of sedation with midazolam. CASE SUMMARY: A 15-month-old boy with apneic episodes was sedated with midazolam for 12 days with constant infusion. Half a day after discontinuation of the midazolam the boy became restless, tachycardic, and hyperpyrexia. When midazolam was readministered, all symptoms disappeared. Four days later midazolam was again discontinued… Expand
View on SAGE
ncbi.nlm.nih.gov
50 Citations
Highly Influential Citations
1
Background Citations
11

50 Citations

Citation Type

Citation Type

Severe Withdrawal Syndrome Possibly Associated With Cessation of a Midazolam and Fentanyl Infusion
  • 10
  • PDF
Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens.
  • 203
Withdrawal from Lorazepam in Critically III Children
  • 27
Withdrawal symptoms in critically ill children after long-term administration of sedatives and/or analgesics: A first evaluation*
  • 108
  • PDF
Myocardial Ischemia as a Result of Severe Benzodiazepine and Opioid Withdrawal
  • 15
  • PDF
Midazolam: a review of therapeutic uses and toxicity.
  • 232
Adverse reactions to the withdrawal of opioids and benzodiazepines in paediatric intensive care.
  • 30
Clinical Pharmacology of Midazolam in Infants and Children
  • J. Blumer
  • Medicine
  • Clinical pharmacokinetics
  • 1998
  • 129
Midazolam Responsive Oculogyric Crisis, Oral Automatisms, Akinesia and Rigidity Induced by Sedation Withdrawal in a Child
Withdrawal symptoms in children after long-term administration of sedatives and/or analgesics: a literature review. “Assessment remains troublesome”
  • 96
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 11 REFERENCES
Precipitation of Benzodiazepine Withdrawal following Sudden Discontinuation of Midazolam
  • 19
Withdrawal reaction after long-term therapeutic use of benzodiazepines.
  • 285
Sedative/Hypnotic Dependence: Patient Stabilization, Tolerance Testing, and Withdrawal
  • 37
Development of physical dependence on midazolam by oral self-administration
  • J. Falk, M. Tang
  • Psychology, Medicine
  • Pharmacology Biochemistry and Behavior
  • 1987
  • 11
Tolerance and physical dependence to a short-acting benzodiazepine, midazolam.
  • 24
Midazolam‐induced benzodiazepine withdrawal syndrome
  • 25
Chronopharmacokinetic Study with Prolonged Infusion of Midazolam
  • 47
Failure of critically ill patients to metabolise midazolam
  • 191
Two cases of benzodiazepine toxicity in children.
  • 11
Acute benzodiazepine withdrawal syndrome after midazolam infusions in children.
  • 72
...
1
2
...