Benzodiazepine Use Attenuates Cortical β-Amyloid and is Not Associated with Progressive Cognitive Decline in Nondemented Elderly Adults: A Pilot Study Using F18-Florbetapir Positron Emission Tomography.

@article{Chung2016BenzodiazepineUA,
  title={Benzodiazepine Use Attenuates Cortical β-Amyloid and is Not Associated with Progressive Cognitive Decline in Nondemented Elderly Adults: A Pilot Study Using F18-Florbetapir Positron Emission Tomography.},
  author={Jun Ku Chung and Shinichiro Nakajima and Shunichiro Shinagawa and Eric Plitman and M. Mallar Chakravarty and Yusuke Iwata and Fernando Caravaggio and Bruce G. Pollock and Philip Gerretsen and Ariel Graff-Guerrero},
  journal={The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year={2016},
  volume={24 11},
  pages={
          1028-1039
        }
}
  • Jun Ku Chung, Shinichiro Nakajima, +7 authors Ariel Graff-Guerrero
  • Published in
    The American journal of…
    2016
  • Psychology, Medicine
  • OBJECTIVE It is inconclusive as to whether benzodiazepines (BZDs) are related to cognitive deterioration in the elderly populations. Animal studies suggest that γ-aminobutyric acid A receptor agonists, such as BZDs, may prevent Aβ-neurotoxicity and reduce β-amyloid (Aβ). However, no studies have investigated the effects of BZD use on Aβ in humans. METHODS This cross-sectional, prospective study using Alzheimer's Disease Neuroimaging Initiative sites in the United States and Canada on… CONTINUE READING

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