Benzodiazepine Receptors on Primary Cultures of Mouse Astrocytes

@article{Tardy1981BenzodiazepineRO,
  title={Benzodiazepine Receptors on Primary Cultures of Mouse Astrocytes},
  author={M. Tardy and M. F. Costa and B. Rolland and C. Fages and P. Gonnard},
  journal={Journal of Neurochemistry},
  year={1981},
  volume={36}
}
Abstract: Benzodiazepines bind to glial membranes on a single type of site, with a high affinity (KD= 5 × 10−9 M) on about 100 fmol of sites per mg protein. The number of binding sites is increased when the membranes are treated with Triton X‐100. Antiepileptic drugs such as clonazepam and phenobarbital and hypnotic drugs such as Ro‐11‐3128 and Ro‐11‐6896 are able in pharmacological concentrations to displace [3H]flunitrazepam from its glial binding sites. 
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References

SHOWING 1-10 OF 16 REFERENCES
Cellular localization of [3H]-diazepam receptors
Benzodiazepine receptor: demonstration in the central nervous system
The binding of [3H]diazepam to rat brain homogenates.
GABA metabolism in cultured glial cells
Distribution of anticonvulsant drugs in gray and white matter of human brain.
...
1
2
...