Benzodiazepine Dependence

@article{Marriott1993BenzodiazepineD,
  title={Benzodiazepine Dependence},
  author={Sarah Marriott and Peter Tyrer},
  journal={Drug Safety},
  year={1993},
  volume={9},
  pages={93-103}
}
SummaryBenzodiazepine dependence is a frequent complication of regular prescriptions for 4 weeks or longer, occurring in almost one-third of patients. Although it is also manifested by tolerance to drug effects and occasional drug seeking behaviour, particularly in those prone to drug abuse, most dependence is characterised by a withdrawal syndrome on stopping treatment. The withdrawal syndrome includes symptoms of anxiety and those of perceptual disturbance such as depersonalisation… Expand
Use and Discontinuation of Hypnosedative Medications
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Intravenous flumazenil infusion to treat benzodiazepine dependence should be performed in the inpatient clinical setting for high risk of seizure
TLDR
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Indications for benzodiazepines include acute stress reactions, episodic anxiety, fluctuations in generalised anxiety, and as initial treatment for severe panic and agoraphobia. Expand
The diagnosis and management of benzodiazepine dependence
  • H. Ashton
  • Medicine
  • Current opinion in psychiatry
  • 2005
TLDR
Benzodiazepine dependence could be prevented by adherence to recommendations for short-term prescribing (2–4 weeks only when possible), and withdrawal from dependent patients is feasible and need not be traumatic if judiciously, and often individually, managed. Expand
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IS THERE A RATIONALE FOR PRESCRIPTION OF BENZODIAZEPINES IN THE ELDERLY? REVIEW OF THE LITERATURE
TLDR
Benzodiazepines (BZDs) constitute the most widely used symptomatic treatment of insomnia and anxiety and may easily be withdrawn during a short period in most patients who are habituated to a low dose, if an initial phase with dose reduction and psychological support are provided. Expand
Benzodiazepines in epilepsy: pharmacology and pharmacokinetics
TLDR
Among these BZDs, clorazepate has a unique profile that includes a long half‐life of its active metabolite and slow onset of tolerance, which could theoretically help minimize adverse events. Expand
Use of benzodiazepines and detoxification with methadone
TLDR
A systematic study on the behavior profile of a patient admitted to a prison hospital, who is a benzodiazepines user consecutive to admission into a methadone administration program, finding a strong positive correlation. Expand
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
TLDR
The present overview aimed at analyzing the literature to illustrate withdrawal after decrease, discontinuation, or switch of psychotropic medications based on the drug class, finding that benzodiazepines should be substituted by medications that cause less dependence such as antidepressants and antipsychotics runs counter the available literature. Expand
Withdrawal of Benzodiazepines in The Elderly Inpatients: How To Do It? Yafll› Hastalarda Benzodiazepinlerin Kesilmesi: Nas›l Yap›lmal›?
TLDR
There is a general awareness that BZD use is inappropriate in many patients, and therefore discontinuation should be recommended whenever possible, and long-term use of these drugs should be actively discouraged. Expand
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Withdrawal of anxiolytic agents such as ethanol, barbiturates, and benzodiazepines may result in a syndrome characterised in its most severe form by delirium and seizures, which could underlie the severe symptoms associated with tranquilliser withdrawal. Expand
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