Benzoctamine-a study of the respiratory effects of oral doses in human volunteers and interactions with morphine in mice.

  title={Benzoctamine-a study of the respiratory effects of oral doses in human volunteers and interactions with morphine in mice.},
  author={H J Utting and Barbara J. Pleuvry},
  journal={British journal of anaesthesia},
  volume={47 9},
A double-blind trial has been performed to investigate the respiratory effects of low oral doses of benzoctamine, and to compare them with diazepam and a placebo. The displacement of the carbon dioxide response curves indicated that whilst diazepam caused respiratory depression, benzoctamine had a variable effect. Some volunteers showed depression, but most showed stimulation. Peak respiratory effects were seen 1 hr after oral administration, returning to normal 2-3 hr after administration. It… 

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