Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5).

@article{Delpn1999BenzocaineEA,
  title={Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5).},
  author={Eva Delp{\'o}n and Ricardo Caballero and Carmen Valenzuela and M{\'o}nica Longobardo and Dirk Snyders and Juan Luis Tamargo},
  journal={Cardiovascular research},
  year={1999},
  volume={42 2},
  pages={510-20}
}
OBJECTIVE The aim of this study was to analyze the effects of a neutral local anaesthetic, benzocaine, on a cardiac K+ channel cloned from human ventricle. METHODS Experiments were performed on hKv1.5 channels stably expressed on mouse cells using the whole-cell configuration of the patch clamp technique. RESULTS At 10 nM, benzocaine increased the current amplitude ("agonist effect") by shifting the activation curve 8.4 +/- 2.7 mV in the negative direction, and slowed the time course of… CONTINUE READING