Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue.

Abstract

Oral cancer, originating from smoking-induced lesions of the basal cells in the complex stratified oral epithelium, is difficult to treat. Early detection of premalignant lesions, e.g., leukoplakia, has suggested the possibility of chemopreventive measures, such as topical application of antimutagenic/antiproliferative dietary or pharmaceutical agents. As… (More)

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@article{Walle2006BenzoApyreneinducedOC, title={Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue.}, author={Thomas Walle and U. Kristina Walle and David Sedmera and Mitch Klausner}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2006}, volume={34 3}, pages={346-50} }