Benzo[k]fluoranthene enhancement and suppression of 17beta-estradiol catabolism in MCF-7 breast cancer cells.

@article{Arcaro1999BenzokfluorantheneEA,
  title={Benzo[k]fluoranthene enhancement and suppression of 17beta-estradiol catabolism in MCF-7 breast cancer cells.},
  author={Kathleen F. Arcaro and Yi Yang and John F. Gierthy},
  journal={Journal of toxicology and environmental health. Part A},
  year={1999},
  volume={58 7},
  pages={413-26}
}
It previously was shown that benzo[k]fluoranthene (BkF), a polycyclic aromatic hydrocarbon frequently detected in environmental samples, increases catabolism of 17beta estradiol (E2) in human breast cancer cells. Data in the present paper demonstrate that BkF both increases and inhibits the catabolism of E2 in MCF-7 breast cancer cells, and that the in vitro BkF increase and inhibition are dependent on the concentration of BkF and the length of the incubation period. A radiometric assay was… CONTINUE READING