Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts

@article{Du2005BenzoapyreneinducedCC,
  title={Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts},
  author={Hong Ju Du and Ning Tang and Bing Liu and Bao Rong You and Fu Hai Shen and Meng Ye and Ai Gao and Chuan Huang},
  journal={Molecular and Cellular Biochemistry},
  year={2005},
  volume={287},
  pages={79-89}
}
Treatment of cells with carcinogen Benzo[a]pyrene (B[a]P) allows cells to evade G1 arrest and induces cells abnormal proliferation. However, the mechanisms of its action at cellular level are not well understood. To address this question, normal human embryo lung diploid fibroblasts (HELF) were selected in the present study. We found that exposure of cells with 2.5 μM of B[a]P for 24 h resulted in a decrease of G1 population by 11.9% (P < 0.05) and a increase of S population by 17.2% (P < 0.05… CONTINUE READING
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References

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SHOWING 1-10 OF 78 REFERENCES

The effect of dibenzo[a,1]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: the induction of DNA adducts, expression of p53 and p21 (WAF1) proteins and cell cycle distribution

  • B Binkova, Y Giguere, P JRRossner, M Dostal, RJ Sram
  • Mutat Res
  • 2000
Highly Influential
4 Excerpts

Pouyssegur: CyclinD1 expression is regulated positively by the p42/p44MPAK and negatively regulated by the p38/HOGMAPK pathway

  • N Josee, Lavoie, +4 authors Jacques
  • J Biol Chem
  • 1996
Highly Influential
4 Excerpts

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