Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment.

@article{Park2006BenzoapyreneinducedDD,
  title={Benzo[a]pyrene-induced DNA damage and p53 modulation in human hepatoma HepG2 cells for the identification of potential biomarkers for PAH monitoring and risk assessment.},
  author={Sun-Young Park and Sun‐mi Lee and Sang-Kyu Ye and Sun-Hee Yoon and Myung Hee Chung and Jinhee Choi},
  journal={Toxicology letters},
  year={2006},
  volume={167 1},
  pages={
          27-33
        }
}
To identify potential biomarkers for the monitoring and risk assessment of benzo[a]pyrene (BaP), the oxidative stress-related DNA damage and p53 modification were investigated in human hepatoma HepG2 cells. Benzo[a]pyrene exposure induced a decrease in the cell viability, but increased the antioxidant enzyme activity as well as the DNA and lipid damage. The p53 protein activation appeared to have been a downstream response to the benzo[a]pyrene-induced DNA damage, suggesting p53 plays important… Expand
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