Benzo[a]pyrene exposure increases toxic biomarkers and morphological disorders in mouse cervix.

  title={Benzo[a]pyrene exposure increases toxic biomarkers and morphological disorders in mouse cervix.},
  author={Meilii Gao and Yongfei Li and Ying Sun and Walayat Shah and Shuiyun Yang and Yi-Li Wang and Jiangang Long},
  journal={Basic & clinical pharmacology & toxicology},
  volume={109 5},
Benzo[a]pyrene (BaP) is a representative compound of polycyclic aromatic hydrocarbons exerting cytotoxicity and genotoxicity in the human liver, lung, stomach and skin. However, the toxic effect of BaP on cervical tissue remains unclear. This study was carried out to investigate the toxic effects of BaP on the cervix of ICR mice. Female mice were treated with BaP by intraperitoneal injection and oral gavage at a dose of 2.5, 5 and 10 mg/kg body-weight, twice a week for 14 weeks. BaP treatment… CONTINUE READING


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