Benzo[a]pyrene decreases global and gene specific DNA methylation during zebrafish development.

Abstract

DNA methylation is important for gene regulation and is vulnerable to early-life exposure to environmental contaminants. We found that direct waterborne benzo[a]pyrene (BaP) exposure at 24μg/L from 2.5 to 96hpf to zebrafish embryos significantly decreased global cytosine methylation by 44.8% and promoter methylation in vasa by 17%. Consequently, vasa… (More)
DOI: 10.1016/j.etap.2013.02.014

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