Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts and increased p53 protein in mouse skin.

@article{Bjelogrlic1994Benzoapyrene78diol910epoxideDNA,
  title={Benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts and increased p53 protein in mouse skin.},
  author={Nina Bjelogrlic and Markus J. M{\"a}kinen and Frej G Stenb{\"a}ck and Kirsi V{\"a}h{\"a}kangas},
  journal={Carcinogenesis},
  year={1994},
  volume={15 4},
  pages={
          771-4
        }
}
p53 protein expression has been shown to increase in response to DNA damage in cell culture systems. We have studied p53 expression and benzo[a]pyrene (B[a]P)-induced DNA-damage in the form of benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE)-DNA adducts as measured by synchronous fluorescence spectrophotometry (SFS) in B[a]P-treated C57BL/6 mouse skin. Polyclonal murine antibody CM5, which is comparable to human CM1, detecting both wild-type and mutated protein, was used. BPDE-DNA adducts reached… CONTINUE READING
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